… development and carcinogenesis. In this review, we summarize the recent studies in DNA
methylation … their potential role in gene silencing in development and disease. Although the …

… DNA Methylation in the Early Embryo In order to understand how DNA methylation may be
involved in the regulation of gene expression during normal development, it was important to …

… development in the human brain than was previously available. Although previous efforts
to comprehensively measure DNA methylation … features of brain development 16 , our study …

… two developmental periods, primordial germ cell (PGC) specification and the early embryo,
in which DNA methylation … principles of DNA methylation in mammalian development and set …

… Here, we show the involvement of epigenetic DNA methylation (DNAme) in metabolic … , and
with subsequent development of complications over an 18-yr period in the blood DNA of 499 …

… plays a critical role in silencing specific genes during development and cell differentiation.
The intrinsic mutagenicity of 5-mC, activation of proto-oncogenes through hypomethylation, …

… , we describe a genomewide DNA methylation assay that identifies CpG methylation on the
… (T m ) of DNA. We show that this denaturation analysis of methylation differences method …

… DNA methylation is an important modification in development. Though developmental
changes in DNA methylation … as in pluripotent genes, developmental genes, and tissue specific …

… Our results indicate that development of a complex … of DNA methylation over several cell
divisions, as seen in the mouse 3 . In theory, sudden global demethylation/de novo methylation …

… , and that DNA methylation has regulatory roles in … DNA methylation during development
are a dynamic, widespread, and tissue-specific process involving both DNA methylation …